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　　随着人们年龄的增长，他们的肌肉往往会萎缩和减弱，尤其是在缺乏使用的情况下。随着肌肉的持续萎缩，日常工作更难完成，摔倒的风险也会增加。一个研究小组正在通过关注一种与衰老相关的酶来梳理这种肌肉损失背后的原因，他们将这种酶命名为“衰老酶”。

　　这种酶是15-羟基前列腺素脱氢酶，或15-PGDH。它会分解一种叫做前列腺素E2的蛋白质。这种蛋白质激活肌肉干细胞的增殖，使受损的肌肉再生。

　　

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　　Stem cell biologist Helen Blau of Stanford University School of Medicine and colleagues previously found that blocking 15-PGDH in old mice restored their withered muscles and improved their strength after a month of treatment. On the flip side, young mice lost muscle and became weaker after their levels of this enzyme were increased for a month.

　　Blau’s team has now found that 15-PGDH accumulates in the muscles of old mice as the connections that allow communication between muscles and nerves are lost, another consequence of aging. Treating old mice for one month with a drug that inhibits 15-PGDH restored these connections, called synapses, between muscle fibers and motor nerve cells, and boosted the animals’ strength, the team reports in the Oct. 11 Science Translational Medicine. Those synapses are how the brain directs muscles to move.

　　The findings suggest that blocking the gerozyme 15-PGDH may be a way to help recover strength that has diminished due to nerve injuries, motor nerve cell diseases or aging.

　　Questions or comments on this article? E-mail us at?[email?protected] | Reprints FAQ

　　Aimee Cunningham is the biomedical writer. She has a master’s degree in science journalism from New York University.

　　

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